Why vancomycin levels

Outreach Solutions Tactics Articles Events. Utilization Management Algorithms. Test Catalog. Download Test. Useful For Suggests clinical disorders or settings where the test may be helpful Preferred test for monitoring vancomycin therapy Monitoring trough concentrations drawn at steady-state in selected patients receiving vancomycin therapy.

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Predictors and clinical outcomes of persistent methicillin-resistant Staphylococcus aureus bacteremia: a prospective observational study. Korean J Intern Med. J Burn Care Res. Clinical response and nephrotoxicity according to the trough serum vancomycin concentration among patients with methicillin-resistant Staphylococcus aureus bacteraemia. Milan; Abstract P Efficacy and safety of linezolid versus vancomycin for the treatment of complicated skin and soft-tissue infections proven to be caused by methicillin-resistant Staphylococcus aureus.

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Vancomycin MICs do not predict the outcome of methicillin-resistant Staphylococcus aureus bloodstream infections in correctly treated patients. The next dose is then given 6 hours after the loading dose. Use actual body weight for dose calculations, including obese patients, up to the maximum recommended doses. Take a trough level before the 2nd dose is due and with hold the dose until the result is known.

Seek specialist advice for subsequent dosing. Vancomycin levels should be repeated until there are two consecutive levels within target range. After this, vancomycin levels can be repeated every 3 days or whenever there is a significant change in bodyweight, serum creatinine or if the dose has been adjusted. Vancomycin is potentially nephrotoxic and ototoxic especially when used in combination with other nephrotoxic or ototoxic agents eg aminoglycosides and in renal impairment. These features develop quickly and usually subside within an hour but may persist for several hours in some cases.

The Royal Children's Hospital Melbourne. Rapid infusion may cause red man syndrome see Adverse Effects section below Vancomycin levels are required to ensure that the target therapeutic range is achieved see Therapeutic Drug Monitoring section below Continuous infusions of vancomycin in infants aged 0 to 90 days are associated with earlier and improved attainment of target concentrations compared with intermittent dosing Dose Patient age Dosing regimen 0—90 days Continuous infusion recommended.

This level could be a trough level or a random level. Drawing two levels is still an option with Bayesian dosing software and will help to improve the accuracy of the AUC estimate even more. In certain populations like critically ill patients, drawing two levels will be necessary.

But for most patients, Bayesian dosing offers increased sampling flexibility. You may be wondering whether you can still use an online calculator, even when AUC-guided dosing is now recommended.